Monday, 20 September 2010

Stressful Live Events and Suicide

The role of stressful life events in suicide attempts and completed suicides has been a key area of study in the epidemiology of mental disorders.  Although suicidal behavior often occurs in the context of acute and chronic stressor, this does not prove a causal link.  We all could probably report serious life stressors throughout out lives and these could be interpreted as a reason for suicidal behavior.  So these associations could simply be a coincidence and not have anything to do with suicidal behavior.

A recent analysis of the WHO (World Health Organization) World Mental Health Surveys attempts to shed some light on this issue.  This study focussed on traumatic life events, a subset of life stressors that are associated with the development of PTSD.  The traumatic events studied included:
  1. natural and man-made disasters
  2. combat, war and refugee experiences
  3. sexual and interpersonal violence
  4. witnessing or perpetrating violence
  5. death or trauma to a loved one
These more serious stressful life events provide a opportunity focus on events everyone would agree as significant.  The authors then looked at five lifetime categories related to suicide:
  1. suicide ideation
  2. suicide attempt
  3. suicide planning in those with ideation
  4. suicide attempt in those with a suicide plan
  5. suicide attempt in those without a plan
The most common traumatic events reported by respondents across the 20 country survey included: death of a loved one (30.5%), followed by witnessing violence (21.8%), interpersonal violence (18.8%), accidents (17.7%), exposure to war (16.2%) and trauma to a loved one (12.5%).

The authors of the study perform complex analysis of the individual and cumulative effects of traumatic events.  The key findings summarized by these analyses include:
  • experiencing interpersonal or sexual violence appeared to have the strongest effect on suicidal ideation and suicide attempt
  • suicidal ideation and attempts had a dose-response effect with traumatic experiences--the more number of experiences, the higher the risk although this effect plateaued after experiencing about 4 events
  • traumatic effects had limited effect on the progression from suicidal ideation to a suicide attempt
  • effects of traumatic events occurred across low-, middle- and high income countries
  • it was estimated that elimination of traumatic life events could reduce population suicide ideation by 15% and suicide attempts by 22%
The study was not able to analyze the effect on the most important variable--completed suicide.  This would add significant weight to attributing a link between traumatic life events.  Nevertheless, this study provides additional insight into stressful life events and suicide ideation and plan.  Traumatic events appear to be important although playing a relatively minor role.  Presence of a serious mental disorder, i.e. major depression, bipolar disorder, substance abuse, schizophrenia, severe personality disorder continues to be the most important risk factor for suicide.

Photo of Baby Duck in Grass Courtesy of Yates Photography

Stein DJ, Chiu WT, Hwang I, Kessler RC, Sampson N, Alonso J, Borges G, Bromet E, Bruffaerts R, de Girolamo G, Florescu S, Gureje O, He Y, Kovess-Masfety V, Levinson D, Matschinger H, Mneimneh Z, Nakamura Y, Ormel J, Posada-Villa J, Sagar R, Scott KM, Tomov T, Viana MC, Williams DR, & Nock MK (2010). Cross-national analysis of the associations between traumatic events and suicidal behavior: findings from the WHO World Mental Health Surveys. PloS one, 5 (5) PMID: 20485530

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