I have had a chance to review this manuscript in more detail. One of the findings of interest involved secondary marker or secondary phenotypes.
Fifteen genetic loci were identified in this 23andMe sample using a discovery and replication data set.
Secondary phenotypes with the highest correlation with the 17 SNPs identified in the study included (effect) :
- Taking a selective serotonin reuptake inhibitor (SSRI) (.448)
- Any medication for mental health reasons (.421)
- Self-reported anxiety (.323)
- Self-reported panic attacks (.319)
- Early age of onset depression (.283)
- Insomnia (.272)
- Prescription pain medication (.236)
- Obesity with BMI>30 (.216)
- Overweight BMI >27 (.212)
The research team was able to identify one SNP (rs12552 in the OLFM4 or olfactomedin 4 region) that correlated with reporting of panic attacks, use of medication for mental health, pain, insomnia problems, BMI >27 and early age of onset of depression.
This study supports use of self-report of depression diagnosis or treatment of depression for genetic studies. Such approaches may open large data sets for understanding the genetics of neuroscience medicine disorders like depression.
Click on the PMID link to access the study abstract.
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Hyde CL, Nagle MW, Tian C, Chen X, Paciga SA, Wendland JR, Tung JY, Hinds DA, Perlis RH, & Winslow AR (2016). Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nature genetics PMID: 27479909
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